About us
C-Search Clinical Trials Ltd. is an Israeli clinical research consultancy founded in 2016 by Sima Reuven, who has worked in clinical research since 2000. We provide senior-level regulatory, clinical operations, study start-up, monitoring, quality, and market-access support to international pharmaceutical, biotechnology, medical device, diagnostics, and health-tech companies operating in Israel.
We support sponsors and CROs throughout the study lifecycle, from feasibility and site selection through regulatory and ethics submissions, contract and budget coordination, site activation, senior CRA monitoring, vendor coordination, and inspection-ready quality processes.
With direct access to senior professionals and established relationships across the Israeli clinical research environment, C-Search combines local regulatory knowledge with practical operational execution. Through selected collaborations with independent medical, scientific, data, and clinical-trial technology specialists, we can also provide clients with broader support tailored to the needs of each program.
For multinational programs, C-Search can also coordinate with a long-standing network of independent boutique CROs and senior clinical research professionals in selected Western and Eastern European countries.
Israel Regulatory & Market Access Support
C-Search supports international pharmaceutical, medical device, diagnostics, and health-tech companies seeking to enter or expand their activities in Israel. We provide practical, locally grounded support in regulatory pathway assessment, Ministry of Health requirements, local regulatory intelligence, product registration strategy, clinical evaluation, post-marketing activities, and coordination with Israeli clinical, scientific, and operational experts.
Together with our clinical trial start-up experience and access to senior scientific and technology advisory expertise, C-Search helps companies understand both the regulatory pathway and the real operational environment in Israel.
Sima Reuven
With more than 25 years of hands-on experience in clinical research, Sima Reuven leads C-Search's regulatory, study start-up, clinical operations, monitoring, quality, and business development activities. Her experience spans Phase I-IV clinical trials across a wide range of therapeutic areas, working with international sponsors, biotechnology companies, and CROs. She provides clients with direct senior-level support and practical guidance grounded in the realities of conducting clinical trials in Israel.
Melina Arazy, MD
Dr Melina Arazy is a senior clinical development physician with over 20 years' experience across the pharmaceutical, biotechnology, and medical-device industries. She has led and supported global Phase I–III clinical programs, from early development and protocol design through late-stage execution, regulatory submissions, inspections, and product approval.
Her core expertise lies in oncology, hematology, and rare disease drug development, where she brings deep experience in medical monitoring, safety and benefit–risk assessment, and data interpretation across complex international trials. This is complemented by broader therapeutic experience in neurology, respiratory medicine, ophthalmology, women's health, and medical devices.
Dr Arazy has worked extensively with the FDA and EMA, as well as regulatory agencies and clinical programs across Europe, Asia-Pacific, and other global regions. Her work spans medical leadership of complex international studies, protocol and eligibility guidance, investigator and KOL engagement, and close collaboration with cross-functional teams, CROs, and regulatory authorities.
Dr Arazy collaborates with C-Search through her independent consultancy, Melina Arazy Consulting Ltd., providing senior medical and clinical development support tailored to the needs of pharmaceutical and biotechnology companies.
Her services include:
- Medical monitoring for Phase I–III clinical trials
- Protocol design, feasibility, and eligibility review
- Benefit–risk assessment, safety oversight and management support
- Regulatory strategy, submissions, and inspection support
- Collaboration with investigators, sites, and CROs on complex or challenging programs
Ofira Moran, PhD
Clinical Trials and Regulatory Affairs Specialist with over 25 years of diverse experience across clinical research, regulatory submissions, and project management. Proven ability to lead complex, multi-center clinical trials from start-up to close-out, with a therapeutic focus spanning Ophthalmology, Oncology, Neurology, Gastroenterology, Cardiology, Psychiatry, Gynecology, Infectious Diseases, and wound care.
Experienced in a variety of roles, including Start-Up Specialist, Senior Clinical Research Associate (CRA), Clinical Oversight Manager, Associate Director of Clinical Research, and Freelance Project Manager. Successfully collaborated with global pharmaceutical companies, biotech firms, and CROs.
Highly skilled in managing Ministry of Health (MOH) and Ethics Committee (EC) submissions in Israel, with strong knowledge of European regulatory environments and international guidelines. Known for ensuring regulatory compliance, conducting clinical monitoring, managing vendor and site relationships, and maintaining subject safety and data integrity.
Proficient in developing training materials, overseeing clinical documentation, supporting audit readiness, and facilitating collaboration between study teams and stakeholders. Experienced in both remote and on-site environments, bringing flexibility, precision, and strong organizational skills to every project.
Prof. Gabby Sarusi
Prof. Gabby Sarusi is a senior academic and technology leader with extensive expertise in photonics, electro-optics, imaging systems, sensors, nanotechnology, and deep-tech innovation. He is a Full Professor and Head of the Photonics and Electro-Optics Department at Ben-Gurion University of the Negev and previously held senior executive roles at Elbit/Elop, including VP, Chief Scientist and CTO.
At C-Search, Prof. Sarusi supports the evaluation and strategic positioning of innovative technologies in medical devices, diagnostics, AI-enabled healthcare, imaging, sensing platforms, and translational research.